Abstract
Herbal drugs aimed to determine the hepatoprotective activity of aqueous extract of Nyctanthes arbortristis bark (AQENA) against paracetamol-induced liver damage (PILD) in rat models. Four groups of rats (n=6) were givens one daily administration of 1gm/kg (negative control), 25mg/kg silymarin (positive control) and AQENA (500mg/kg) for 7 days fallowed by induction of hepatotoxicity using of paracetamol. Various parameters, such as physical parameters, biochemical parameters and microscopic analysis ware used to evaluate the hepatoprotective activity. Results indicate that bark extract would a significant (p<0.05) hepatoprotective activity against inducers. These observations were supported by the histological finding. Conclusions: Findings indicate that AQENA possesses a potent hepatoprotective activity against paracetamol.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Medical and Biomedical Studies
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.