Evaluation of Hepatic Resection in Liver Metastasis of Gastric Cancer

Yukiko Nonaka,Kazuhiro Hiramatsu,Motoi Yoshihara,Yoshihisa Shibata,Taro Aoba,Takehito Kato,Tadahiro Kamiya

doi:10.1007/s13193-018-0827-6

Yukiko Nonaka, Kazuhiro Hiramatsu + Show 5 more

Open Access

https://doi.org/10.1007/s13193-018-0827-6

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Abstract

Gastric cancer is the second most common malignancy globally and the third most common cause of cancer-related deaths in Japan. In gastric cancer, benefit of surgical resection of liver metastasis, which was shown in colorectal cancer, is not well established. The present study aimed to examine the feasibility of hepatic resection for liver metastasis of gastric cancer. In this retrospective study, we reviewed the medical records of 10 patients with liver-only metastases of gastric cancer who underwent hepatectomy among 2043 patients with gastric cancer who underwent gastric resection between January and December 2016 at a single institution in Japan. Median 1-, 3-, and 5-year overall survival (OS) rates were 78.0%, 33.3%, and 22.2%, respectively, among 10 patients who underwent hepatic resection. There was a significant difference in OS rates between tumors measuring ≥ 5 cm and < 5 cm (hazard ratio [HR] 6.524, 95% confidence interval [CI] 1.145–37.171, p = 0.035). The longest survival was 205 months for one patient who was alive at the time of the analysis. Hepatic resection of liver metastasis in gastric cancer was associated with long-term survival in some patients. Additionally, primary tumor size was associated with long-term survival.

Highlights

Gastric cancer is the second most common malignancy globally and the third most common cause of cancerrelated deaths in Japan
Some studies suggest that hepatectomy is effective against gastric cancer with only liver metastasis, with a 5-year overall survival (OS) ranging from 20 to 40% [1,2,3,4,5,6,7,8,9,10,11], whereas results of other studies investigating the benefit of hepatic resection for liver metastasis of gastric cancer were unclear [12,13,14]
We reviewed the medical records of 10 patients with liver-only metastases of gastric cancer who underwent hepatic resection among 2043 patients with gastric cancer who underwent gastric resection between January and to December 2016 at Toyohashi Municipal Hospital

Summary

Introduction

Gastric cancer is the second most common malignancy globally and the third most common cause of cancerrelated deaths in Japan. Despite considerable advances in overall gastric cancer treatment, approaches for the treatment of gastric cancer metastasizing only to the liver have been controversial. Some studies suggest that hepatectomy is effective against gastric cancer with only liver metastasis, with a 5-year overall survival (OS) ranging from 20 to 40% [1,2,3,4,5,6,7,8,9,10,11], whereas results of other studies investigating the benefit of hepatic resection for liver metastasis of gastric cancer were unclear [12,13,14].

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