Abstract
Diabetes mellitus is a pathology related to changes in glucose metabolism. The hormone insulin acts stimulating intracellular glucose metabolic pathways. The increase in cGMP signaling has the potential to increase insulin sensitivity in the muscle and can stimulate the secretion of this hormone by pancreatic beta cells. Sildenafil (SIL) is a potent peripheral vasodilator that acts attenuating the catabolism of cGMP thus increasing the signaling of the pathways involving the protein kinase G. The present study aimed to evaluate the effect of the sildenafil on hematological and biochemical paramethers in hyperglycemic rats. 55 male Wistar rats were separated into 4 groups: G1 (control), G2 (streptozotocin), G3 (streptozotocin + 10 mg/kg sildenafil) and G4 (streptozotocin + 15 mg/kg sildenafil). The animals received sildenafil during seven days before the application of streptozotocin, maintaining the treatment for another 3 weeks. After euthanasia, hematological and biochemical analyzes were performed. The group that received the highest dose of SIL, showed a decrease in leukocytes compared to the G2 group (p <0.05). In addition, G2 presented thrombocytopenia. Therefore, sildenafil appears to decrease the number of inflammatory cells in hyperglycemic rats in a dose dependent manner.
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