Evaluation of Hemato-Biochemical Parameters, Body and Organ Weight and Reproductive Profile Changes in Response to Receiving Different Levels of Indomie Noodles in Albino Rats

Abstract

The Indomie noodles are an instant noodle sold dried in packets or cups. The noodles are quick and easy to make and can be eaten as a snack or part of the main meal. This study was designed to examine the possible effect of different levels of Indomie noodles on the hematological biochemical profile, organosomatic index and male fertility indices in healthy adult albino rats. In an experimental study, twenty male rats of average weight 115 g (divided into four groups) and twenty female rats of average weight 100 g (divided into four groups). Each group consists of five rats. Group A is the control group and was fed with standard rat feed. In contrast, groups B, C and D were supplied with 25 %, 50 % and 75 % Indomie instant noodles cooked and spiced with the seasoning. The administration was carried out for 8 w. The result showed that the body weight, expressed as growth rate, showed that rats exposed to the 75 % Indomie noodle formulated diets had significantly minimum growth rates than controls and other two different groups. There was a significant increase (p<0.05) in the organosomatic index (kidney, liver, brain and testes) of rats fed on a diet containing 75 % Indomie noodles. There was a significant (p<0.05) increase in lymphocytes percentage, with a decrease in monocytes and granulocyte percentages compared to the control group. Red blood cell indices examination showed a reduction in mean cell volume, mean cell hemoglobin and mean cell hemoglobin concentration value. A diet containing 75 % Indomie noodles appeared to the highest significant decrease in total serum protein and serum uric acid with a significant increase of alkaline phosphatase and blood urea at 25 %, 50 % and 75 % in comparison to the control group. However, aspartate aminotransferase results show a significant difference at 75 % compared to 0 %. On the other, evaluation of various sperm parameters showed there was a significant reduction in sperm concentration, motility and viability between treated groups in comparison to the untreated group in response to an increase in the percent of Indomie noodles in the diet and their plasma testosterone levels of the treated groups decreased insignificantly than those of the control group.