Abstract
Recent studies have shown a correlation between Helicobacter pylori (H. Pylori) infection and the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). The aim of this study was to investigate the relationship between H. Pylori infection and hematimetric indices in patients with dyspepsia symptoms. Overall, 448 patients who underwent gastroscopy were analyzed retrospectively. Histopathological evaluation of biopsies according to H. pylori presence was classified as H. Pylori positive and negative groups, which are analyzed in relation with hematimetric indices. NLR and PLR measurements did not show a statistically significant difference between H. pylori negative and positive groups (p > 0.05). NLR revealed a negative correlation between hemoglobin (HGB), iron, and ferritin measurements in the correlation analysis of the H. Pylori positive group (r = −0.133, p = 0.031; r = −0.270, p = 0.002; r = −0.162, p = 0.032). Again, with PLR, there was a negative correlation between HGB, mean corpuscular volume (MCV), iron, and ferritin measurements (r = −0.310, p = 0.001, r = −0.187, p = 0.002, r = −0.335, p = 0.001; r = −0.290; p = 0.001). The results of our study do not reveal an association between H. pylori presence and inflammatory response, which is evaluated by NLR and PLR measurements in patients with dyspepsia. However, low serum iron and ferritin values of H. pylori-positive patients suggest the effect of H. pylori on iron metabolism.
Highlights
Helicobacter pylori (H. pylori) is one of the most common chronic bacterial infections in humans
There were no differences in hemoglobin (HGB), mean corpuscular volume (MCV), leukocyte, neutrophil, lymphocyte, platelet, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) measurements between H. pylori-negative patients and H
We investigated the H. pylori infection activity in patients with dyspepsia symptoms and the relationship between inflammatory markers, neutrophil/lymphocyte ratio and platelets/lymphocyte ratio
Summary
Helicobacter pylori (H. pylori) is one of the most common chronic bacterial infections in humans. It affects about 50% of the world’s population. Dyspepsia is a collection of symptoms, which has a differential diagnosis and heterogeneous pathophysiology. It is seen at least in 20% of the population [2]. While 25% of patients with dyspepsia symptoms have an underlying organic cause (organic dyspepsia), 75% of them have no underlying organic cause in diagnostic evaluation (functional dyspepsia) [3,4]. H. pylori gastritis is one of the prominent factors in the pathophysiology of functional dyspepsia (FD). H. pylori infection among dyspeptic patients is estimated to be up to 70%, it showed regional differences [5]
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