Evaluation of health risk associated with consumption of food crops from electronic waste dumpsite using albino Wistar rat’s model: Bayelsa state Nigeria case study

Abstract

The alterations in some important health biomarkers associated with consumption of food crops harvested near E-waste dumpsite in Bayelsa State, Nigeria, was evaluated. Samples of soil, plant, water and sea foods were collected around E-waste dumpsites and control sites for laboratory screening. A standard animal feed was formulated (control group), and the feed formulated from plants harvested from e-waste dumpsites was used to feed the experimental animals (Test group) for a period of three months. The formulated feeds were screened for toxic metals using atomic absorption spectrometry. The study comprises of twenty-eight animals (fourteen each of male and female) of albino wistar strain, weighing 50-100g were divided into two groups of fourteen animals each. Health biomarkers such as C-reactive protein, TNF alpha, creatinine, alanine transaminase (ALT), aspartate transaminase (AST), alanine phosphatase (ALP), platelet count, and oxidative stress parameters were evaluated in both groups. Toxic metals content of samples collected from the E-waste dumpsite revealed significantly (p<0.05) higher levels of Cd, Co, Ni and Pb, which exceeded WHO permissible limits, compared with the control (p<0.05) site. Significant (p<0.05) differences between the test and control group for serum C-reactive protein, TNF alpha, creatinine concentrations, ALT, AST, ALP activities, platelet count, and oxidative stress parameters of the test group were all significantly (p<0.05) higher than the control group, suggesting the presence of oxidative stress trigger(s) among animals in the test group and these results were further affirmed by the histology results as presented. Conclusively, this study highlighted a strong correlation between consumption of food crops cultivated near E-wastes dumpsites and potential associated health risks. Hence, demands public awareness and a call on governments and concerned regulatory bodies to ensure and enforce ethical E-waste management and disposal practices to minimize E-waste exposure and toxicity.