Abstract
The article introduces findings of the study on surfactant-induced effects on the growth and maturation of rat pups, prenatally exposed to Laprol-604. The adverse influence of Laprol-604 exposure on rat fetuses was identified in the immediate postnatal period (0-3 days) and later. Laprol-604 induced neonatal mortality within the period of three days, reduced litter size, resulted in low-birth-weight of progeny and a decrease in body weight gain in rat pups. Somatic growth retardation produced by Laprol-604 persisted during postnatal period and was accompanied by a delay in integumental morphogenesis of rat pups. Closer examination revealed an impact of Laprol-604 on delayed opening of the external auditory canal, resulting in an altered sequence of craniofacial development, such as the time of eyelid opening, incisor eruption. Maternal Laprol-604 exposure adversely affected the release and erection of the pinna. In summary, Laprol-604 had dosage-dependent developmental toxicity effect on progeny of female rats exposed to Laprol-604 during gestational period.
Highlights
High production volumes and widespread use of surfactants have been an environmental concern since the early 1960s
The presence of surfactants and their biodegradation products in different environmental compartments can invoke a negative effect on the biota [8, 10, 11].The toxicity of surfactants on living organisms has been summarized in scientific literature [1, 2, 11]
Laprol-604 administration decreased statistically significant litter size in the 3rd group (5.48±0.21), 2nd (7.07±0.15) and 1st (8.20±0.12) groups compared with controls (9.31±0.23) (p
Summary
High production volumes and widespread use of surfactants have been an environmental concern since the early 1960s. The presence of surfactants and their biodegradation products in different environmental compartments can invoke a negative effect on the biota [8, 10, 11].The toxicity of surfactants on living organisms has been summarized in scientific literature [1, 2, 11]. Investigations show that biological action of non-ionic surfactants are characterized by numerous structural metabolic disorders, as well as possibility to condition remote consequences, such as acceleration of immune deficiency, mutagenesis, inhibition of male fertility in rats, adverse reproductive effects and so on [7, 10,11]
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