Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated withMalpighia emarginataJuice

Sandra M Barbalho,Ana Paula Machado Spada,Karla Aparecida Martuchi,Viviane Sazaki,Marie Oshiiwa,Miréia Palhares,Vanessa Sellis Da Silva,Débora C Damasceno

doi:10.1155/2011/173647

Abstract

Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.

Highlights

Diabetes mellitus is a disease characterized by chronic hyperglycemia because of a total or relative lack of insulin [1].Among the many groups of people who suffer from this disease are gestating women
Gestational diabetes leads to modifications in the metabolism of the mother and her offspring caused by the mother’s hyperinsulinemia and hyperglycemia
Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata juice on the glycemic and lipid profile of the offspring of diabetic and nondiabetic Wistar rats

Summary

Introduction

Diabetes mellitus is a disease characterized by chronic hyperglycemia because of a total or relative lack of insulin [1].Among the many groups of people who suffer from this disease are gestating women. Gestational diabetes leads to modifications in the metabolism of the mother and her offspring caused by the mother’s hyperinsulinemia and hyperglycemia. These conditions affect the fetal metabolism during the gestational period and extend throughout the life of the offspring [2, 3]. The presence of obesity and diabetes is more frequent in childhood and adolescence when there is a history of maternal or gestational diabetes. In these conditions, metabolic disorders can affect the growth and metabolism of descendants and subsequent generations [6, 7]

Objectives

Methods

Conclusion