Evaluation of Gentamicin's Antimicrobial Resistance Pattern Against Uropathogens in a Tertiary Health Care Center in Dhaka City, Bangladesh

Mohammad Asaduzzaman ,Farha Matin Juliana ,Ariful Islam ,Nazia Zaman ,Ashok Kumar ,Md Abu Jafor ,Md Ebadat Hosen ,Md Jhaangir Alam ,Nazmul Hossain ,Biswajit Das ,Lubatul Arbia ,Tasneem Ehsan ,Azmal Morshed ,Syed Shahariar Bappy

doi:10.7176/jhmn/67-08

Abstract

Treatment of UTI patients with aminoglycosides is a familiar incidence. Resistance of antibiotics is also a familiar incidence but it is alarming when it goes to a high ratio. The vital public health problem in developing country like Bangladesh is resistance of antibiotics to different types of bacteria causing UTI and the rates of these bacterial resistances are changing for various antibiotic therapy. Our aim was to assess the susceptible pattern of Gentamicin a drug of Aminoglycosides group against uropathogens. A total of 12943 urine samples were collected in 2016 (Jan-Dec) and out of which 1236 (9.55%) were bacteriologically positive out of these isolated 95.1% were gram negative and 4.9% gram positive organism. Male were found more prone to get UTI under 10 years and between 51-90 years of age and female were more affected in 10 to 50 years and over 90 years of age group. E. coli was the most prevalent (83.9%) isolate followed by Klebsiella spp. (6.7%), Staphylococcus aureus (2.6%), Pseudomonas spp. (2.2%), Enterococcus spp. (2.0%) and Proteus spp. (1.1%). The most predominant organism Acinetobacter spp. (100%) were found sensitive to Gentamicin in both male and female patients and Enterococcus spp. in male (62.5%) and female (58.8%) were found resistant. Around 37.4% male and 32.5% female were found resistant to E.coli. Keywords : Gentamicin, Aminoglycosides, UTI, Resistance, Uropathogen. DOI : 10.7176/JHMN/67-08 Publication date :October 31 st 2019

Highlights

IntroductionUrinary Tract Infection (UTI) is a predominant infection all over the world but it is more prevalent in developing south Asian countries like Bangladesh
Antibiotic resistance is an increasing threat to life and morbidity and mortality
This study aimed to evaluate the pattern of antimicrobial susceptibility of bacteria isolated from patients with Urinary Tract Infection (UTI) seen at the IBN SINA diagnostic center, Badda, Dhaka, Bangladesh

Summary

Introduction

Urinary Tract Infection (UTI) is a predominant infection all over the world but it is more prevalent in developing south Asian countries like Bangladesh. Besides every year about 150 million people are affected by UTIs. Worldwide at a cost of about US$6 billion and even UTIs have demonstrated significant morbidity and mortality. Worldwide at a cost of about US$6 billion and even UTIs have demonstrated significant morbidity and mortality. They are the second most common types of infection in humans accounting for 8.3 million doctor’s visit annually in USA.[2] UTI can be nosocomially ubiquitous in clinical environment so that prevalence rate of uropathogens is being alarmingly accelerated.[1] Urinary tract infection is more common in female than male, because of the short length of the urethra and its proximity to anus. Sex, immunosuppression and urological instruments may affect prevalence of UTIs.[3]

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