Abstract
Our study was aimed to evaluate the effects of cadmium on chick embryo liver tissue. 10th, 11th and 12th day old Bobcock strain chick embryos were exposed to cadmium individually, by in ovo treatment. These concentrations 40, 50, 60 μg of Cadmium at different time intervals i.e., 24, 48, 72 hr, were administered to developing chick embryo. On the 13th study day, blood and the liver tissues collected were tested for genotoxic and lipid peroxidation assays. In this study, the presence of micronucleated erythrocytes and also various abnormal cells in the blood smear indicated the role of cadmium-induced genotoxicity. Current findings showed that frequency of micronucleated erythrocytes increased with increased doses of cadmium and time interval. MDA levels were high in cadmium exposed group compared to control group. These findings suggest the genotoxic and an oxidative stress mechanism in cadmium-induced liver tissue enhances damage.
Highlights
An earth’s crust natural element, cadmium (Cd), is usually found as a mineral in combination with other elements such as oxygen, chlorine, or sulfur
The total number of the micronucleated erythrocytes showed a significant increase with increasing concentrations of cadmium at different time intervals
The MN formed in erythrocytes, cells accumulate more in blood since spleen is yet not functional to clear them from blood
Summary
An earth’s crust natural element, cadmium (Cd), is usually found as a mineral in combination with other elements such as oxygen, chlorine, or sulfur. The MN test evaluates the frequency of MN formation in a proliferating cell population in vitro [33,34], as well as in vivo and in various tissues in ovary, bone marrow, peripheral blood, liver, and in fetal cells of rodents and humans [35,36] Owing to their precision in analysis and widely accepted application in genotoxicity testing, the MN was performed in the present study to evaluate the genotoxic potential of the selected heavy metal, Cadmium in developing embryos for evaluation of damage either at cell or chromosomal level
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