Abstract
ObjectiveMultiple chemical sensitivity (MCS) is a chronic medical condition characterized by symptoms that the affect an individual’s response to low-level chemical exposure. In this study, we identified a chemical sensitive population (CSP) and investigated the effect of genetic polymorphisms on their risk of chemical sensitivity.MethodsA quick environment exposure sensitivity (QEESI) questionnaire was used to survey 324 Japanese male workers whose DNA samples had been collected and stored. The following genes, which encode enzymes affecting the metabolic activation of a large number of xenobiotic compounds, were selected and analyzed in order to determine their influence on genetic predisposition to CSP: cytochrome P450 (CYP) 2E1, N-acetyl transferase (NAT) 2, glutathione S-transferase (GST) M1, GSTT1, GSTP1, low Km aldehyde dehydrogenase (ALDH2), and superoxide dismutase (SOD) 2.ResultsSignificant case-control distributed differences were observed in SOD2 polymorphisms and allele frequency distribution in high chemical sensitive subjects. Both the significant adjusted OR of 4.30 (95% CI, 1.23–15.03) and 4.53 (95% CI, 1.52-13.51) were observed in SOD2 Ala/Ala and Val/Ala compared to Val/Val and in SOD2 Ala/Ala compared to Val/Ala compared to Val/Val genetic analysis in the high chemical sensitivity case-control study.ConclusionsWe observed that high chemical sensitive individuals diagnosed by using Japanese criteria as MCS patients were more significantly associated with SOD2 polymorphisms.
Highlights
Individuals experiencing multiple chemical sensitivity (MCS) often report symptoms from various organs related to inhalation of multiple unrelated airborne chemicals in concentrations below what is normally associated with toxicological responses [1]
Individuals previously diagnosed with Multiple chemical sensitivity (MCS) were all defined as the chemical sensitive population (CSP) case group, one of them was classified as high chemical sensitivity
This study focused on determining if there were any associations between chemical sensitivity and genetic polymorphisms
Summary
Individuals experiencing multiple chemical sensitivity (MCS) often report symptoms from various organs related to inhalation of multiple unrelated airborne chemicals in concentrations below what is normally associated with toxicological responses [1]. MCS is a chronic medical condition characterized by symptoms that affect an individual’s responses to low-level chemical exposure. These chemicals can include pesticides, plastics, and paint fumes. In general the reported symptoms are attributed to previous chemical exposure and recur on subsequent exposure to similar or structurally unrelated chemicals at levels normally considered to be nontoxic [2]. The clinical characteristics of MCS patients are usually evaluated using questionnaires such as the environmental exposure and sensitivity inventory (EESI)
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