Abstract
Background Human species and guinea pigs have to obtain vitamin C (VC) from food because they are unable to synthesize ascorbic acid due to the absence of the gene that encodes L-gulonolactone oxidase (Gulo). The spontaneous bone fracture (sfx) mouse is a mouse model which is deficient in the synthesis of VC because of the deletion in Gulo gene. Because muscle forces are a strong determinant of bone structure, particularly during the process of growth and development, we examined the gene expression of muscle in sfx mice.
Highlights
Human species and guinea pigs have to obtain vitamin C (VC) from food because they are unable to synthesize ascorbic acid due to the absence of the gene that encodes L-gulonolactone oxidase (Gulo)
Evaluation of gene expression in muscle in mouse model lacking of vitamin C synthesis Yonghui Ma, Yan Jiao, Fusheng Zhao, Weikuan Gu*
The spontaneous bone fracture mouse is a mouse model which is deficient in the synthesis of VC because of the deletion in Gulo gene
Summary
Human species and guinea pigs have to obtain vitamin C (VC) from food because they are unable to synthesize ascorbic acid due to the absence of the gene that encodes L-gulonolactone oxidase (Gulo). Evaluation of gene expression in muscle in mouse model lacking of vitamin C synthesis Yonghui Ma, Yan Jiao, Fusheng Zhao, Weikuan Gu* From 11th Annual UT-ORNL-KBRIN Bioinformatics Summit 2012 Louisville, KY, USA. Background Human species and guinea pigs have to obtain vitamin C (VC) from food because they are unable to synthesize ascorbic acid due to the absence of the gene that encodes L-gulonolactone oxidase (Gulo).
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