Abstract
Objective: The present study was undertaken to evaluate the gastroprotective potential of Cajanus cajan seed aqueous extract (CCSE) on experimentally induced gastric ulcer in albino rats. Methods: Preliminary acute toxicity study was conducted to determine the oral median lethal dose (LD50). Twenty (20) male rats divided into 5 groups (A-E) of 4 animals each were used. Group A (normal control) and B (ulcer model) received 10ml/kg distilled water. Groups C, D and E received Cimetidine (100mg/kg b.w intraperitoneally), 250mg/kg and 500mg/kg b.w of CCSE orally respectively, once daily for seven (7) days. On Day 8, gastric ulcers were induced in groups B – E using 80% ethanol (1ml/rat) prior to sacrifice. Ulcer indices were determined on excised stomach tissues prior to further processing for histological examination. Results: The LD50 of CCSE is greater than 5g/kg b.w. Cimetidine and CCSE treatments showed statistically significant decrease (p<0.05) in ulcer indices compared to group B (ulcer model). Histological features revealed noticeable preservation of the gastric mucosa in consistence with the macroscopical findings. Conclusion: The present study revealed that C. cajan seed extract possesses gastroprotective properties against ethanol-induced gastric ulcers.
Highlights
Peptic ulcer is among the common defects of the gastrointestinal walls and may manifest on the mucosal lining of the stomach or the small intestine [1]
The highest ulcer index (UI) of 3.25±0.48 was recorded in the ulcer model group, whereas statistically significant (p
Values are expressed as Mean±standard error of mean (SEM) * and # = p
Summary
Peptic ulcer is among the common defects of the gastrointestinal walls and may manifest on the mucosal lining of the stomach or the small intestine [1] It presents as abdominal stress, most commonly in the upper part of the abdomen and epigastric region. Extracts from plants have gained importance in pharmaceutical industries as source of new drugs which have shown promising results in combating various disease conditions including gastric ulcer. They have remained chief alternative for most people due to their availability, cheaper cost, and higher safety margin. Many medicinal plants with antiulcerogenic potential have been documented in scientific literature [8,9,10]
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