EVALUATION OF GASTROPROTECTIVE EFFECTS OF METHANOL EXTRACT OF TEPHROSIA VILLOSA AGAINST EXPERIMENTALLY INDUCED ULCERS IN WISTAR RATS

Pinkey Rawal,Soma Pramanik,C Ramesh

doi:10.22159/ijpps.2021v13i11.41277

Abstract

Objective: The present research work was designed to investigate the gastroprotective potentials of methanol extract of Tephrosia villosa. Methods: The aerial parts of Tephrosia villosa were dried under shade, powdered and deffated with petroleum ether and then marc leftover was subjected to methanol extraction using soxhlet apparatus using soxh-let apparatus. Antiulcer activity of methanol extract was determined against stress-induced and aspirin-induced ulcers in experimental animal models. The total number of ulcers formed, ulcer index, percentage inhibition, ulcerated area, protected area, pH and Total acidity were parameters in the study. Results: Methanol extract of Tephrosia villosa at medium (200 mg/kg) and high (200 mg/kg) could significantly (P<0.01) reduced the total number of ulcers formed, ulcer index, ulcerated area and total acidity in therapeutic groups compared to vehicle control and thereby significantly (P<0.01) increased percentage inhibition of ulcers and protected area which was evident by the significant rise in pH of gastric content. The effect of extracts was dose-dependent and results were comparable to that of standard drug omeprazole. Conclusion: The results obtained from the present work suggest that the methanol extract of Tephrosia villosa possess significant anti-ulcer potentials against experimentally induced ulcers in albino rats.

Highlights

There is increased incidence of peptic ulcer worldwide due to stressful lifestyle and eating habits which includes both gastric and duodenal ulcers
The methanol extract of Tephrosia villosa was safe up to dose of 2000 mg kg-1 b.w. and caused neither mortality nor any signs of clinical abnormality in the tested animals during the observation period of 14 d after administration of the highest dose
We found that there is a significant rise in percentage inhibition of ulcer formation, protected area and pH of gastric content

Summary

Introduction

There is increased incidence of peptic ulcer worldwide due to stressful lifestyle and eating habits which includes both gastric and duodenal ulcers. It is one of the most prevalent gastrointestinal tract diseases that affect a wide range of people globally [1]. The pathophysiology of peptic ulcer disease was attributed to the imbalance between the offensive factors The use of non-steroidal anti-inflammatory drugs (NSAIDs), irregular diet, emotional stress, excessive alcohol use and smoking are all the principal etiological factors associated with the peptic ulcer [3]. The drug treatment of ulcers is commonly focused on the suppression of acid secretion and the enhancement of gastric protection [4]. Many of the existed medicines have limitations, especially when they were used against ulcers with complex etiologies [4]

Methods

Results

Discussion

Conclusion