Abstract
Evaluation of Functionalized Spider Silk Matrices: Choice of Cell Types and Controls are Important for Detecting Specific Effects.
Highlights
Evaluation of functionalized spider silk matrices: choice of cell types and controls are important for detecting specific effects
The ideal scaffold for engineering and regeneration of tissues would be a replica of the extracellular matrix (ECM), which is unique for each tissue type
For improving cell attachment to biomaterials, the RGD (Arg-Gly-Asp) peptide motif is commonly used. This peptide is found in fibronectin, vitronectin, bone sialoprotein (BSP), and collagen VI and is recognized by the αvβ3 integrin (Arnaout et al, 2005)
Summary
Evaluation of functionalized spider silk matrices: choice of cell types and controls are important for detecting specific effects. A commentary on Recombinant spider silk with cell binding motifs for specific adherence of cells by Widhe M, Johansson U, Hillerdahl CO, and Hedhammar M.
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