Abstract
Conventional mesoporous silica (SM) and ethylene-bridged periodic mesoporous organosilica (PMO) were synthesized and modified with mono-functional octadecylsilane (C18). The materials were comprehensively characterized, before and after surface modification. Small angle X-ray diffraction, N2 adsorption–desorption measurement, scaning electron microscopy and transmission electron microscopy showed that all the prepared materials had non-symmetrical 3-D wormhole-like mesostructure and spherical morphology. Fourier transform infrared spectroscopy, 29Si MAS NMR and 13C MAS NMR spectroscopy, elemental and thermogravimetric analysis demonstrate the successful funcionalization of the materials with 0.242–0.388 and 0.204–0.402mmol of C18 per g of SM-C18 and PMO-C18 silicas, respectively. HPLC columns packed with the prepared materials were tested by using a RP test mixture. From chromatographic parameters it was found that the separation power primarily depends on surface coverage. PMO-C18-2 and SM-C18-3 silicas were tested as a potential stationary phase for the effective separation of a mixture of five steroids. Separation for the five hormones was observed with the PMO-C18-2 column, which can be ascribed to the ethane groups in the mesoporous framework of this material.
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