Abstract
SUMMARY AND CONCLUSIONS Nine dogs were studied 3 to 8 months after total orthotopic homotransplantation of the mitral valve. Another dog, which had mitral insufficiency of 3 years’ duration, was studied before and 6 weeks after replacement of the anterior leaflet. Two dogs were found to have completely normally functioning valves, 1 had pure mitral stenosis, 2 had mild mitral stenosis and associated mild mitral insufficiency, and 3 had mild or moderate mitral insufficiency. One animal had severe mitral insufficiency, and the dog with transplantation of the anterior leaflet had normal mitral valve function. One dog, restudied 16 months postoperatively, shows no deterioration of the good results displayed early after surgery. Its ability to increase the cardiac output nearly threefold above the resting value in response to exercise demonstrates the excellent function of the left ventricle and transplanted valve. In normal dogs, minimal “mitral regurgitation” is usual. This factor and the problem of nonrepresentative sampling from the left atrium render the upstream-sampling dye method for quantitation of regurgitation of limited reliability.
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