Abstract
BackgroundSonchus arvensis is used in the treatment of various human aliments as a traditional medicine in Pakistan. In the study its various fractions are characterized for scavenging of diverse free radicals.ResultsResults of the present study revealed that various fractions of Sonchus arvensis significantly scavenged the free radicals (DPPH·, ABTS·+, ·OH, superoxide), however its methanolic fraction is more potent than other fractions. Significant correlation was found between DPPH·, ABTS·+, superoxide radical and total antioxidant activity with total flavonoids and phenolics contents. Phytochmical analysis revealed the presence kaempferol, quercetin, orientin, rutin, hyperoside, catechin and myricetin.ConclusionFrom the present data it is concluded that various fractions of Sonchus arvensis significantly scavenged the free radical, which might be due the presence of polyphenolic constituent.
Highlights
Sonchus arvensis is used in the treatment of various human aliments as a traditional medicine in Pakistan
A balance is present between amounts of free radicals produced in our body and antiradicals enzymatic and non enzymatic system to quench these and protect the body from their harmful effects [1]
Free radicals including superoxide anions, hydrogen peroxide and hydroxyl are extensively involved in oxidative damage at cellular level
Summary
In the study its various fractions are characterized for scavenging of diverse free radicals. Free radicals including superoxide anions, hydrogen peroxide and hydroxyl are extensively involved in oxidative damage at cellular level. Growing number of evidences suggest that reactive oxygen species (ROS) induced biochemical changes are decisive factors in various chronic human disease such as diabetes mellitus, cancer, atherosclerosis, arthritis, inflammation and neurodegeneration [2]. Human body has developed many mechanisms both enzymatic and nonenzymatic to eliminate ROS but not enough in severe oxidative stress conditions. The most studied system to fight against oxidative stress is to combat their level in body by supplying with greater amount of natural antioxidants, which can be attained by elevated use of vegetables and fruits.
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