Abstract
(chromogranin A immunoreactive) and more specifically ECL cell derived (hietidine decarboxylase immunoreactive and Sevier-Munger positive). Moreover, a substantial part of gastric carcinomas from man and especially those classified as diffuse according to Lauren, expressed markers compatible with neuroendocrine (chromogranin A), and more specifically of ECL cell (Sevier-Munger) origin. Whereas the number of positive tumor cells were low in most carcinomas studied by conventional immunohistochemical reaction, the number of positive cells increased markedly when applying the tyramide signal amplification for the chromngranin A immunoitetection. CONCLUSION: ECL ceils give rise to gastric carcinomas not only in rodents, but also in man.
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