Evaluation of Few Immunological Parameters in Patients with Chronic Renal Failure in Najaf

Abstract

Kidney failure is a chronic disease currently spreading worldwide, and one of its most important complications. Many indicators can be used to detect kidney disease early, which, if not treated, will eventually lead to failure. Kidney disease often leads to death. The study aimed to find a relationship between chronic renal failure and some immunological parameters and its relationship to the mechanism of dialysis, if it was hemorrhagic or peritoneal This study was conducted at the Kidney Center in Al-Sadr Teaching Hospital, Al-Najaf, and lasted from September 2022 to May 2023, including 57 males with chronic renal failure and 33 males. Listening male subjects who were considered as a control group. It was divided into age groups from 20 to 70, the duration of infection from 1 to 4 years, 5 to 7 and 8 to 15 years, and the body mass index included normal, excess, and obesity for patients with hemodialysis, peritoneal dialysis, and patients who did not reach the stage hemodialysis. The study concluded significant differences in the immunological indicators MCP-1 NTN-1, IL-1, α-TNF in the renal failure serum compared with healthy subjects. There was a positive relationship in the MCP-1, NTNT-1,IL-1, α TNF level. The results showed that there are significant differences p < 0.05 in age groups and body mass index in patients with renal failure compared with healthy subjects. There are no significant differences p > 0.05 with the duration of infection in patients with chronic renal failure compared with healthy controls. The presence of significant differences predicted kidney failure, p < 0.05, in the MCP-1 immunological indicators NTN-1, IL-1, α-TNF –TNF, The approved ROC table in patients with renal failure showed that the highest area of the biomarker NTN-1 and the lowest area is the biomarker α- TNF and immunological indicators are considered as predictors of early diagnosis of chronic renal failure.