Abstract
1546 Background: The collection of cancer family history (FH) is a key component for risk assessment in adult cancer patients, but is not routine in pediatric oncology. We collected FH on all newly diagnosed pediatric cancer (PC) patients presenting at Primary Children’s Hospital to determine the feasibility of routine FH collection and risk prevalence for hereditary cancer syndromes. Methods: Parents of newly diagnosed children (age 0 to 20) were approached for enrollment and given a FH questionnaire to complete and return by mail assessing FH in first- and second-degree relatives. A genetic counselor contacted all participants by phone to review the reported history or to obtain a FH from those who did not return the form. Criteria for genetics referral were based on NCCN or peer-reviewed criteria. Results: Of the 91 families that completed a FH, 24 (26%) were considered eligible for further genetic risk evaluation. 16 (17%) warranted referral based on the child’s tumor type or personal/ FH criteria, 8 ...
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