Evaluation of factors that intervention of palliative care team contributes to quality-of-life improvement of Japanese patients with advanced cancer.

Abstract

e19517 Background: Quality of life (QOL) has not been evaluated in Japanese patients with advanced cancer by EORTC QLQ C-15 PAL, which was developed to measure QOL in palliative care. The patient characteristic that relates to EORTC QLQ C-15 PAL score is not known. Thus, we investigated the factor that related to EORTC QLQ C-15 PAL domain score change before and after the palliative care team (PCT) intervention. Methods: We executed the prospective study to the in-patient who had hoped for the PCT intervention. Patients were asked to complete the self-administered questionnaires according to EORTC QLQ C-15 PAL on before and day 7 of PCT intervention. We analyzed the QOL domain score changing and its correlation to clinical and physiological variables such as age, gender, performance status (PS), and baseline domain scoring in the multivariate stepwise linear regression and bootstrap analysis. Results: Thirty-five patients were recruited, and of those 26 completed the questionnaires and 9 were withdrawn from the trial due to discharge. Median age was 58.5 (range: 22-81), Male: Female = 19:7, PS 0:1:2:3:4 = 2:11:6:7:0, lung cancer = 17 (65%). In the multivariate analysis, the stepwise protocol detected significant baseline valuables which influence each QOL domain. Physical function (r(2)=0.56); baseline physical function scores (coefficient -0.70, [95%CI -1.03, -0.38], p<0.001), gender (male) (38.1, [19.4, 56.7], p<0.001). Emotional function (r(2)=0.70); baseline emotional function score (-0.62, [-0.86, -0.38], p<0.001), gender (male) (15.7, [0.21, 31.27], p=0.047), age (-0.61, [-1.11, -0.11], p=0.018), PS (2-4) (24.75, [10.69, 38.82], p=0.002). Global QOL (r(2)=0.46); baseline global QOL score (-0.7, [-1.02, -0.38], p<0.001). Conclusions: We observed significant associations of factors, such as baseline score, age, gender (male) and PS (2-4) with increased QOL domain score after PCT intervention. The rise of the baseline score and the age of the patient were suggested that a negative factor in the QOL improvement.