Abstract
This study aimed to investigate the predictive factors for uveitis recurrence (UR) risk in Behcet's disease (BD) patients. BD patients (n=164) with a history of uveitis were recruited, and demographic data, clinical features, and laboratory tests were recorded. Uveitis was defined as anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis referring to the “International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease”. In total, there were 70 UR patients and 94 non-UR patients. Compared to non-UR patients, UR patients appeared to be older and presented with increased uveitis occurrence rate and times within 3 months, oral ulcers occurrence rate, as well as higher concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and serum amyloid A (SAA). Multivariate logistic model disclosed that uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA independently predicted higher risk of UR. Furthermore, receiver operating characteristic curve analysis showed that the combination of uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA exhibited a high predictive value for UR risk with an area under the curve of 0.983 (95%CI: 0.969−0.998). In conclusion, uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA might be potential predictive factors for UR risk in BD patients, which can help in prevention and management of the disease.
Highlights
Behcet’s disease (BD) is a severe systemic debilitating vasculitis featuring recurrent oral aphthous ulcers, genital ulcers, uveitis, as well as skin lesions, which usually involves the musculoskeletal system, eyes, nervous system, vascular beds, gastrointestinal tract, and cardio-pulmonary system [1]
Patients, and only a few have proposed that the percentage of Treg cells, presence of brainstem atrophy in initial magnetic resonance imaging, and increased scintigraphic uptake occurring in symptomatic acral joints by bone scintigraphy act as useful predictive factors for ocular, neuro, and joint involvement in BD patients, respectively [3,4,5]
An interesting study discloses that increased scintigraphic uptake occurring in symptomatic acral joints by bone scintigraphy presents with predictive value for joint involvement in BD patients [5]
Summary
Behcet’s disease (BD) is a severe systemic debilitating vasculitis featuring recurrent oral aphthous ulcers, genital ulcers, uveitis, as well as skin lesions, which usually involves the musculoskeletal system, eyes, nervous system, vascular beds, gastrointestinal tract, and cardio-pulmonary system [1]. One of the most common factors of disability caused by BD, has been reported to affect nearly 70% of BD patients [1]. As the most common manifestation of ocular involvement, uveitis is a chronic recurrent disease with characteristics of explosive attacks of severe inflammation that can lead to damage of the intraocular structures [2]. In order to address this aspect, this present study enrolled 164 BD patients with a history of uveitis, with the purpose to investigate the predictive factors for UR risk in BD patients
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