Abstract
Tuberculosis (TB) treatment default contributes to the perpetuation of the epidemic and increases the risk of emergence of new forms of multidrug-resistant TB. The aim of this study was to identify the factors associated with treatment default in Chad. This prospective study interviewed 286 patients with pulmonary TB in three centers, recruited at the beginning of treatment. We compared patients who completed the treatment to the treatment defaulters. A logistic regression model was fit to identify factors associated with default. 32% of patients defaulted, that is, abandoned treatment. The multivariate analysis demonstrated that a low educational level and ignorance of the contagious nature of TB were associated with treatment interruption. TB education, patient assistance, and active tracing of patients who fail to return can help to prevent abandonment of TB treatment.
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