Abstract
Desmodium gyrans DC is a well-known herb for its antidote, cardiac-tonic and wound healing activities. The present study was aimed for wound healing potential of the ethanol extract of Desmodium gyrans leaves in the form of simple ointment using two types of wound models in rats, viz. excision wound and dead space wound. The results were comparable to standard drug ciphadin ointment, in terms of wound contraction, tensile strength, histopathological and hydroxy proline content. Histopathological study showed significant increase in fibroblast cells, collagen fibres and blood vessels formation. All parameters were observed significant (p<0.01) in comparison to control group.
Highlights
The world health organization (WHO) urged researchers to examine whether traditional medicines produced any beneficial clinical results [1]
The results showed that the ethanolic extract ointment possesses a definite prohealing action
In excision wound healing model the ethanolic extract of the leaves of Desmodium gyrans showed significant increase in percentage closure of excision wounds by enhanced epithelization significant increase, (p
Summary
The world health organization (WHO) urged researchers to examine whether traditional medicines produced any beneficial clinical results [1]. Numerous biologically active plants are discovered by evaluation of ethnopharmacological data, and these plants may offer the local population immediately accessible therapeutic products [2]. Some of these plants are used in the management of fresh wounds, while others for the treatment chronic wounds. The common ways of the treatment are either direct application of crushed fresh plant on the wound or repeated wash of the wound with a plant decoction. Despite the wide spread use of local plants in wound healing, only few of them have been investigated for their potential usefulness using excision and incision wound models by rats [3,4]
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