Evaluation of Environmental Contamination by Heavy Metals and Relationship with Cardiovascular Risk in a Population of Barcarena-PA.

Abstract

Heavy metals are widely used to sustain the living standards of the modern world. Due to their prevalence, the risk of human exposure is an increasing threat to public health as they can cause negative health effects, such as cardiovascular diseases (CVDs). In this study, the objective was to evaluate clinical-epidemiological and biochemical parameters in relation to the overall risk score (ERG) of developing CVDs in 112 individuals aged 30 to 74years living in the city of Barcarena-PA. The results of heavy metal contamination and biochemical parameters were applied in the ERG calculation. A significance level of p < 0.05 was adopted in the statistical tests. The values were high for chromium (Cr) (45.8%) and aluminum (Al) (98.6%). As for the ERG for CVDs, they obtained low risk (42%), medium risk (40%), and high risk (18%). In individuals with high ERG, a significant association was detected with increasing age group, in individuals ≥ 60years (p < 0.0001). The relationship between concomitant Al and Cr intoxication and increased ERG was also significant (p = 0.0016). The probability of high cardiovascular risk among individuals contaminated by Al + Cr is higher than that of individuals contaminated by Al alone (p = 0.0074). Such evidence indicates that continuous environmental monitoring in the municipality of Barcarena is of extreme importance, since the population is in a situation of vulnerability in relation to their health.