Abstract
Purpose: The pathogenesis of OA often begins from an injury to articular cartilage, which establishes chronic, low-grade inflammation that eventually promotes matrix degradation leading to the destruction of cartilage. Currently, there are no agents that efficiently slow or inhibit this process. Pluripotent stem cell-derived chondrocytes (PDC) represent a promising new tool for cartilage repair, but in vivo, specification of these cells remains unclear.
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