Evaluation of Endoscopic Sinus Surgery Combined with Dexamethasone in the Treatment of Chronic Rhinosinusitis

Abstract

The purpose of this study is to explore the efficacy of endoscopic sinus surgery combined with dexamethasone for treating chronic rhinosinusitis. A total of 123 chronic rhinosinusitis patients diagnosed by magnetic resonance imaging and cochlear implant in the otolaryngology department of the First Peopleâs Hospital of Chuzhou City from January 2018 to January 2019 were selected. They were randomly divided into the control group (n=61) and the experimental group (n=62). After endoscopic sinus surgery, the control group used only normal saline for nasal cleaning, while the experimental group added dexamethasone nasal spray for regular treatment. After outpatient follow-up every 3 mo, the sinonasal outcome test-20 scores, Lund-Kennedy scores, olfactory tests, and therapeutic effects were compared between the two groups. Before treatment, compared to the control group, there was no significant difference in the sinonasal outcome test-20 scores (38.78±5.42 vs 39.08±5.73) and Lund-Kennedy scores (17.35±3.21 vs 17.40±3.35) of the experimental group. After treatment, during the follow-up period of 3, 6, and 12 mo, the sinonasal outcome test-20 scores were (9.38±2.10 vs 2.10±0.45) and the Lund-Kennedy scores were (7.45±1.65 vs 2.23±0.73) between the control and the experimental groups, which were significantly different between the two groups(P<0.05). The olfactory test scores of the experimental group was significantly higher (P<0.05). After treatment for 12 mo, the cure rate of the experimental group was 95.16 %, which was significantly www.ijpsonline.com 127 Indian Journal of Pharmaceutical Sciences Special Issue 5, 2020 higher than that of the control group cure rate of 90.16 %. In terms of the recurrence rate after treatment, there was a statistically significant difference between the two groups in the follow-up period of 3 mo (22.95 vs 12.90 %) and 6 mo (14.75 vs 6.45%). However, there was no significant difference in the followup period of 12 mo (1.45 vs 0). Endoscopic sinus surgery combined with dexamethasone could ameliorate the clinical symptoms of chronic rhinosinusitis patients, improve their quality of life. It also has a better long-term effect, which is worth to consider.