Abstract
Familial adenomatous polyposis (FAP) is a disease inherited in an autosomal dominant fashion. Most FAP patients develop upper gastrointestinal polyps; especially those in the antrum and duodenum are usually neoplastic. The aim of this study was to evaluate the prevalence of gastroduodenal polyps in Iranian FAP patients. 28 patients affected by FAP underwent front-view and side-view endoscopy. Papillary biopsies were performed in all patients. Location of polyps, their number and size, pathology study, patient general information (gender, age, family history of FAP or colorectal cancer and gastroduodenal polyps) were analyzed. Gastric polyps were seen in 39.3 % of patients. Some 72.7% of the affected individuals had fundic gland polyps and 36.36% had hyperplastic polyps. Duodenal adenoma was observed in 25% of patients. While 57% of patients had tubular adenoma with low grade dysplasia, 42.8% showed tubulovillous adenoma with low grade dysplasia. Findings of this study indicated that the prevalence of gastroduodenal polyps in FAP patients is high and dysplasia may be evident in duodenal polyps. Therefore, it appears that routine gastroduodenal endoscopy in FAP patients is necessary.
Highlights
Colorectal cancer (CRC) is one of the most common cancers worldwide and its burden is increasing in Asian Pacific region countries including Iran (Pourhoseingholi et al, 2009; Somi et al, 2014)
Findings of this study indicated that the prevalence of gastroduodenal polyps in Familial adenomatous polyposis (FAP) patients is high and dysplasia may be evident in duodenal polyps
Cases were selected among patients who have been registered at gastroenterology and liver disease Research Center, Taleghani Hospital. 28 patients participated in this study
Summary
Colorectal cancer (CRC) is one of the most common cancers worldwide and its burden is increasing in Asian Pacific region countries including Iran (Pourhoseingholi et al, 2009; Somi et al, 2014). The most FAP patients develop upper gastrointestinal polyps, especially those in the antrum and duodenum are usually neoplastic (Offerhaus et al, 1999). Most FAP patients develop upper gastrointestinal polyps; especially those in the antrum and duodenum are usually neoplastic. Papillary biopsies were performed in all patients Location of polyps, their number and size, pathology study, patient general information (gender, age, family history of FAP or colorectal cancer and gastroduodenal polyps) were analyzed. Conclusions: Findings of this study indicated that the prevalence of gastroduodenal polyps in FAP patients is high and dysplasia may be evident in duodenal polyps. It appears that routine gastroduodenal endoscopy in FAP patients is necessary
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