Evaluation of Efficacy of Cabbage Juice (Brassica Oleracea Linne) As Potential Antiulcer Aggent and Its Effect on the Haemostatic Mechanism of Male Albino Wistar Rats.

Abstract

Ulcers are usually identified by abdominal pain, but this can be accompanied by vomiting red or black blood, blood in stool, unexplained weight loss and appetite changes (Corriher, 2010). Evaluation of efficacy of cabbage juice (Brassica oleracea linne) as a potential antiulcer agent and its effect on the haemostatic mechanism of male albino wistar rats was studied using 42 male albino wistar rats. The randomly selected animals of average weight were distributed into 3 groups (A, B, C). Groups B and C were systematically induced with peptic ulcer before they were gavaged with the cabbage juice (Group B) and the standard ulcer drug (Group C). Result of the study showed that cabbage juice healed ulcer fasted within 15 days compared to the standard cimethidin ulcer drug (28 days; Table 2). The bleeding and clotting times of test rats administered with cabbage juice were shorter than those on the standard ulcer drug and the corresponding control (Table 3). The result also indicated that cabbage juice does not significantly affect on the haemapoietic systems since the results of all the complete blood count, carried out remained normal after at the end of extract feeding. It could be deduced that cabbage juice contains some antiulcer principles that prevents further breakage of the lining of gastroduon denal system,