Evaluation of effects of diet on serum obestatin levels in over-weight patients with polycystic ovary syndrome

Abstract

Objective: The aim was to evaluate effects of diet on serum obestatin levels in overweight or obese patients with polycystic ovary syndrome. Materials and Methods: This was prospective case-control study (preliminary study). Twenty-two overweight and obese women diagnosed with polycystic ovary syndrome (PCOS) and 22 body mass index (BMI) and age-matched non-PCOS controls. Serum obestatin levels were measured using enzyme-linked immunosorbent assay. Effects of weight loss on obestatin level and relationships between obestatin levels and hormonal and biochemical parameters were evaluated in PCOS. Results: In PCOS group, there was no significant difference in the obestatin levels between before and after the diet. In controls, there was no significant difference in the weight loss or the obestatin levels at baseline and after the diet. In both groups, there was no correlation between obestatin levels and homeostasis model assessment-insulin resistance or BMI before or after the diet. In PCOS group, obestatin levels were negatively correlated with high-density lipoprotein before the diet and obestatin levels were negatively correlated with waist-hip ratio after the diet. Conclusions: To the best of our knowledge, this is the first study to investigate the effects of weight loss on obestatin levels in over-weight and obese women with PCOS. We found no difference in the obestatin levels before and after the diet in PCOS and control groups. Our findings suggest that different mechanisms play critical roles in the regulation of obestatin levels when BMI is relatively higher. There is a need for large-scale and long-term follow-up, prospective studies to evaluate the effects of obestatin in PCOS.