Abstract
Objective: The study was to test water extract ofKundurby treatingchronic renal failure that induced by Cadmium chloride CdCl2.Method: CdCl2. at a concentration of 5 mg /kg body. wt./day of rat at chronic level with drinking water for six weeks as animal model.measuring some predicate biomarkers functional common kidney was done serum creatinine and novel biomarker measured KIM-1 and NAGL, Cystatin C, demonstrate that a regular oral intake of CdCl2 solution (in drinking water) for 45 days.Results: There is significant increase of Serum Urea, creatinine, KIM-1, NAGL and Cystatin C, when compared with control group, also indicate there is significant increase in serum biomarkers for kidney injury. After the treatment with water extract of Kundurby different concentrations 10,20, and 30 mg/kg all these Urea, Scr., KIM-1, NAGL and Cystatin C were significantly decrease when compared with CdCl2 group, compared with control group and after the treatment the damages were not found or minimize. At this exposure of CdCl2.Conclusion: The biomarkers KIM-1, NAGL and Cystatin C may be good predictive indicator of chronic renal failure, plant extract may be having a highly effect for treating the renal failure and showed highly response to treatment.
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