Abstract
Background:Cardiovascular disease has been associated with multiple risk factors such as dyslipidemia. However, the focus has recently shifted towards some novel risk factorsi.e. infection from periodontitis.Given this background, we aimed to assess the effect of periodontal therapy on some CVD risk factors including Total Cholesterol (TC), Low-Density Lipoprotein(LDL), High-Density Lipoprotein(HDL), Triglycerides(TG) and C-Reactive Protein (CRP). Fasting Blood Sugar (FBS) level has also been measured.Methods:Thirty patients (12 male and 18 female) who had severe periodontitis were tested for different blood parameters; namely Total Cholesterol (TC), Low-Density Lipoprotein (LDL), High-Density Lipoprotein(HDL), Triglycerides (TGs), C-Reactive Protein (CRP) and Fasting Blood Sugar (FBS). Enzymatic colorimetric methods were applied to measure all the parameters’ values except for CRP. The first stage of periodontal treatment comprised oral hygiene instruction as well as scaling and root planing. After 1 month, at the next stage, open flap debridement surgery was performed on all 4 quadrants of the mouth. The blood parameters were reassessed and compared with the baseline values after 3 months. Two patients (female) failed to participate in the follow-ups. The Pearson's and Spearman's correlation coefficients were calculated to determine whether changes in laboratory variables are associated with age and average probing depth or not.Results:All the assessed parameters related to 28 patients showed mean reduction which proved to be significant for CRP (p=0.011) and cholesterol (p=0.035). Among all parameters, only CRP level was found to have a significant positive correlation with pocket depth. Other blood parameters' relationship with age and probing depth proved to be insignificant.Conclusion:Considering the results, periodontal treatment may significantly lower lipid profile serum levels and some inflammatory factors.
Highlights
Cardiovascular Disease (CVD) is regarded as the main cause of myocardial infarction and the leading cause of death worldwide [1]
16 The Open Dentistry Journal, 2019, Volume 13 factors that may be attributed to these situations has been intensified and recent evidence implicates the causality of chronic infection and inflammation in CVD [3]
The possible role of chronic infection in the development of CVD suggests that atherosclerosis, the major type of CVD might be considered itself as an inflammatory response to injurious factors in all stages, i.e. initiation, growth and complication of the atherosclerotic plaque [4]
Summary
Cardiovascular Disease (CVD) is regarded as the main cause of myocardial infarction and the leading cause of death worldwide [1]. Gender, dyslipidemia, high blood pressure, smoking and diabetes mellitus have been widely accepted as classical CVD risk factors. CVD imposes a great amount of health-related costs and diminishes individual productivity. Because of these problems and additional cost for health provider systems, the search for additional risk. The focus has recently shifted towards some novel risk factors i.e. infection from periodontitis. Given this background, we aimed to assess the effect of periodontal therapy on some CVD risk factors including Total Cholesterol (TC), LowDensity Lipoprotein(LDL), High-Density Lipoprotein(HDL), Triglycerides(TG) and C-Reactive Protein (CRP).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
