Abstract
Dry eye syndrome (DES) is caused by multi‐factors and it is featured as tear deficiency and eye irritation. Air pollutions, represented as particulate matter (PM), are emerging threat of human health which induce various diseases including DES. However, the pathogenic mechanisms of DES via PM exposure are not completely identified. Though, several in vivo models of PM induced DES have been suggested, these were not properly reflect the phenomena of human who exposed to PM. In this study, we utilized inhalation device to mimic the atmospheric environment of PM exposure. Rats were exposed to urban PM (UPM) for 5 hours a day during 5 days. After exposure, tear volume was reduced in UPM exposure group. In addition, corneal irregularity and corneal epithelial cell apoptosis were significantly increased by UPM exposure. UPM also affected the tear film disruption via mucin‐4 reduction. Our purpose in this study was to demonstrate the application of new in vivo exposure model for DES induced by PM. We suggest that aerosol exposure system of PM can be used for risk assessment of DES.Support or Funding InformationThis study was carried out with the support of ‘R&D Program for Forest Science Technology (Project No. 2017035A00‐1919‐BA01)’ provided by Korea Forest Service (Korea Forestry Promotion Institute). This work was also supported by Korea Institute of Oriental Medicine (Project No. KSN1812080).This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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