Abstract
The objective of the study is to evaluate of drug resistance and treatment outcomes among tuberculosis patients with diabetes mellitus at tertiary care hospital of Sindh, Pakistan. Tuberculosis (TB) is considered as very dangerous infectious disease caused by Mycobacterium tuberculosis orother tubercle bacilli pathogen affects the lungs and it can be spread from person to person through very minute droplet released by infected person via coughing or sneezing.
 Descriptive cross-sectional study was carried out at different Tuberculosis setting located at tertiary care hospital of Sindh, Pakistan for the period of 10 months. Tuberculosis OPD is considered as major health care facility for the TB, MDR-TB and XDR-TB patients for the local population and peripheries. Total 389 samples were collected through purposive sampling techniques. From the given data, there were 209 Males and 180 females, all participants belong to different areas, so 216 patients belong to rural areas, 121 study participants were house wives, 134 were employed and 41 were have their own business. From the clinical data, 229 participants shown positive response with TB smear test, whereas; 156 participants had positive results with TB culture test. 247 patients had previous history of Tuberculosis, 120 had developed drug resistance and 24 had developed multi-drug resistance (MDR). 312 patients were recently diagnosed with Diabetes mellitus and they had one year of duration of diabetes. Complication of tuberculosis developed among 113 patients and complication of diabetes developed among 194 participants. 39 people were using oral therapy for the management of diabetes and 341 participants had successfully completed their therapy and cured whereas 2 patients were died due to complication
 It was concluded from the current research that there were many chances for developing drug resistance and multi-drug resistance among the patients suffering from co-morbid including tuberculosis along with Diabetes mellitus. Proper counseling should be conducted, in order to reduce the complication of either type of disease.
Highlights
Approximately 9 million new cases of Tuberculosis (TB) reported every year and according to WHO reports there were almost 350 million people, who had diagnosed with diabetes mellitus [1,2]
Diabetes Mellitus is considered as major hazardous aspect for the development of tuberculosis cases [3,4] and almost 18% of active tuberculosis patients had diabetes mellitus [5].There was strong correlation between Tuberculosis and Diabetes Mellitus as both disease possess high dominance globally and since last few decades, mortality and morbidity rates of diabetes increased enormously [2,6,7]
[9] Literatures from India, Spain, Turkey and Pakistan elaborate that diabetes with active cases of tuberculosis was very much common among these countries. 25% of multi drug resistant tuberculosis (MDR-TB) patients were having diabetes mellitus [10,11,12,13]
Summary
Approximately 9 million new cases of Tuberculosis (TB) reported every year and according to WHO reports there were almost 350 million people, who had diagnosed with diabetes mellitus [1,2]. Diabetes Mellitus is considered as major hazardous aspect for the development of tuberculosis cases [3,4] and almost 18% of active tuberculosis patients had diabetes mellitus [5].There was strong correlation between Tuberculosis and Diabetes Mellitus as both disease possess high dominance globally and since last few decades, mortality and morbidity rates of diabetes increased enormously [2,6,7]. The cases of multi drug resistant tuberculosis (MDR-TB) are increased very fast [8], so the significance of understanding about the correlation of diabetes and tuberculosis is developing [9] Literatures from India, Spain, Turkey and Pakistan elaborate that diabetes with active cases of tuberculosis was very much common among these countries.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
