Abstract
Abstract— Formation of crosslinks in DNA by various mono‐ and bifunctional furocoumarins plus UVA light in mouse embryo fibroblasts was evaluated by a NaI density gradient centrifugation method. Angelicin and 3‐carbethoxypsoralen did not form any crosslinks: however, angelicin was slightly carcinogenic for mouse skin, whereas 3‐carbethoxypsoralen was not carcinogenic. Psoralen induced DNA crosslinking, in a dose‐dependent fashion and was highly carcinogenic for mouse skin. In contrast to the psoralen‐induced photoadducts (120 per 106 nucleotides) which were left unrepaired, 41% of the 3‐carbethoxypsoralen adducts (30 per 106 nucleotides) were removed during 1 h of dark post‐incubation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
