Evaluation of Diuretic Activity of aqueous extract of Ipomoea batatas (L)

Abstract

A diuretic is any substance that promotes the production of urine. This includes forced diuresis. There are several categories of diuretics. All diuretics increase the excretion of water from bodies, although each class does so in a distinct way. Alternatively, an ant diuretic such as vasopressin, or ant diuretic hormone, is an agent or drug which reduces the excretion of water in urine. In medicine, diuretics are used to treat heart failure, liver cirrhosis, hypertension, influenza, water poisoning, and certain kidney diseases. Some diuretics, such as acetazolamide, help to make the urine more alkaline and are helpful in increasing excretion of substances such as aspirin in cases of overdose or poisoning. Diuretics are often abused by those with eating disorders, especially bulimics, in attempts to lose weight. The antihypertensive actions of some diuretics (thiazides and loop diuretics in particular) are independent of their diuretic effect. That is, the reduction in blood pressure is not due to decreased blood volume resulting from increased urine production, but occurs through other mechanisms and at lower doses than that required to produce diuresis. Indapamide was specifically designed with this in mind, and has a larger therapeutic window for hypertension (without pronounced diuresis) than most other diuretics. The main objective of the present research work is to isolate the bioactive molecules and evaluate the diuretic activity of aqueous extract of Ipomoea batatas the phytochemical analysis of aqueous extract of Ipomoea batatas root showed the presence of various phytochemical constituents such as flavonoids, carbohydrates, tannins, phenol. The effect of aqueous extract of root of Ipomoea batatas on rats with reference to biochemical changes in serum. The group-II (Standard Hydrochlorothiazide 10 ml/kg, p. o) animals showed significant (P<0.01) increase in total urine volume ml/100 gm/hr (10.44 ml). Whereas animals received AEIB significantly (P<0.01) increase in total urine volume ml/100 gm/hr (4.44 and 8.06 ml) and significantly (P<0.05) increased total 200 & 400 mg/kg doses respectively. The results of most several clinical investigations showed the efficacy and safety of carbohydrate, flavonoids are using diuretic activity give a fine action comparative standard drugs. The phytochemical studies revealed the presence of Carbohydrate, flavonoids, Tannins in the AEIB these may be responsible for its pharmacological activities.