Abstract
Ethnopharmacological relevanceTraditional Siddha medicine literature claims that the Amaranthus spinosus Linn. (family: Amaranthaceae) whole plant possesses diuretic property. Aim of the studyTo evaluate the diuretic potential of Amaranthus spinosus aqueous extract (ASAE) in rats. Material and methodsDifferent concentrations of ASAE (200, 500, 1000, 1500mg/kg), thiazide (10mg/kg) and vehicle were orally administered to rats (n=6 animals per group) and their urine output was collected after 24h. Volume, pH, Na+, K+ and Cl− concentrations of urine were estimated. ResultsASAE produced increase in Na+, K+, Cl− excretion, caused alkalinization of urine, showed strong saluretic activity and carbonic anhydrase inhibition activity. These effects were observed predominantly at 500mg/kg dose and there was no dose–response relationship. ConclusionOur study strongly suggests that the Amaranthus spinosus is acting as a thiazide like diuretic with carbonic anhydrase inhibitory activity which restates the claim as diuretic herb in Siddha medicine.
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