Evaluation of disease duration and effect of diabetes mellitus on renal parenchymal diffusion MRI signals in patients with chronic renal failure

Abstract

Objective: It is known that in chronic renal failure (CRF), diffusion weighted (DW) magnetic resonance imaging (MRI) ADC values of the renal parenchyma are reduced. However, the effect of CRF disease duration on renal ADC values is unknown. In this study, the effect of CRF disease duration and accompanying DM on renal parenchymal ADC values was investigated. In this study, abdominal MR examinations of 39 patients with 39 BMD and 30 DM patients whose eGFR was normal. Material and Method: In this study, abdominal MR examinations of 39 CRF and 30 DM patients (eGFR within normal limits) and 59 control subjects were evaluated retrospectively. CRF patients were divided into three groups according to disease duration (<5, 5> 10 < and >10) and were staged as 1-5 according to the eGFR results. ADC measurements were made by two different methods, including a focal small area and the entire parenchyma. The findings were evaluated by statistical analysis according to the duration of CRF, presence of DM, insulin use and dialysis status. Results: ADC values were significantly lower in CRF patients compared to the control group since stage 2 (p <0.05), while there was no significant difference between the control group and stage 1 CRF. ADC values were quite low in dialysis patients (p <0.001). Disease duration, presence of diabetes and insulin use did not significantly contribute to ADC values (p> 0.05). While no significant difference was observed in the ADC measurement results with both methods in the patient groups (p> 0.05), ROI measurements containing the entire parenchyma in the healthy group were statistically significantly lower (p <0.05). Conclusion: In CRF patients, the duration of CRF disease, the presence of DM and insulin use have no significant contribution to renal parenchymal ADC values.