Evaluation of Dis-Lub-Tout, a new co-processed tabletting excipient II. Lubricant property

Abstract

Dis-Lub-Tout was evaluated next to magnesium stearate, MS, for its lubricant property in model tablet formulations prepared with excipients of different deformation mechanisms. At equivalent concentration levels, Dis-Lub-Tout performed better than MS in terms of improving the flow rates of the tested formulations. The lubricant activity of Dis-Lub-Tout was assessed by measuring its effect on the de-compactibility and de-compressibility indexes of the lubricated formulations and on the porosity expansion index of their corresponding tablets. Dis-Lub-Tout generated higher indexes and imparted more adverse effects on the mechanical properties of the tablets. Formulations of MCC (plastically deformed excipient) were more affected. Unlike MS, Dis-Lub-Tout accelerated the disintegration and dissolution of the lubricated tablets. DAI (disintegration accelerating index) and t 50 % (time for the release of 50 % of the tabletted drug) were determined for the tested batches, respectively. The result encourages to design and co-process less expensive excipients of superior properties and multifunctional activities.