Abstract
Objective: The aim of this study is to evaluate the action of the synthetic chalcone 1-phenyl-3-(4-chlorophenyl)-2-propen-1-one to induce pulp healing in rats. Material and Methods: Sixty lower first molars of male Wistar rats were divided into 3 groups (n= 20): control (no treatment); calcium hydroxide and chalcone . After relative isolation, the cavities were prepared using a sterile low-speed ¼ round dental bur. After controlling the hemorrhaging, all the pulp exposures were capped with the capping material, by groups. The cavities were sealed with glass ionomer cement and the repair process was assessed at 21 days of procedure. The data were statistically analyzed using the Fisher exact test (p<0.05). Results: Moderate inflammation was observed in all the experimental groups and significant (p<0.05) reparative dentin (tertiary) formation in the calcium hydroxide and chalcone groups. The chalcone group showed dentinal tubules and a low number of cellular inclusions (p<0.05). Conclusion: The chalcone used in this study indicates potential as an inducer of reparative dentine (tertiary) in a rat model.
Highlights
The dental pulp consists of loose connective tissue, and is responsible for dental vitality through its roles such as dentin nutrition, innervation and tooth defense; this occurs by the formation of new dentin against any aggression
It involves the application of a biomaterial directly over the exposed pulp, in order to stimulate the differentiation of new odontoblasts from stem cells of the pulp
Synthesis of Chalcone The molecule of chalcone 1-phenyl-3-(4-chlorophenyl)2-propen-1-one used in this study was synthesized by Claisen-Schmidt condensation from acetophenone
Summary
The dental pulp consists of loose connective tissue, and is responsible for dental vitality through its roles such as dentin nutrition, innervation and tooth defense; this occurs by the formation of new dentin against any aggression. In order to maintain the pulp tissue histophysiology, given that the survival of the tooth depends directly on the maintenance of pulp vitality, the most commonly used procedures are pulp capping and pulpotomy. The success of these treatments depends on an assessment of the degree of pulp impaired by trauma or bacterial infection of the dentin-pulp complex[2]. The procedure known as direct pulp capping is the most indicated in pulps exposed by mechanical agents or traumas It involves the application of a biomaterial directly over the exposed pulp, in order to stimulate the differentiation of new odontoblasts from stem cells of the pulp. This, in turn, enables a restorative reaction through the formation of tertiary reparative dentin, maintaining pulp vitality and its normal functions[2,3]
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