Abstract
8524Background: This study aimed to investigate the survival difference between right-sided and left-sided pneumonectomy in stage I-IIIA NSCLC patients, and to further develop the best treatment st...
Highlights
Lung cancer has been the most common cancer in China and globally [1, 2]
For 2,683 patients who received pneumonectomy, cancer-specific survival (HR=0.863, 95%CI: 0.771 to 0.965, P=0.010) and overall survival (OS) (HR=0.875, 95%CI: 0.793 to 0.967, P=0.008) were significantly superior of left-sided pneumonectomy compared with right-sided pneumonectomy
Cancer-specific survival (HR=0.847, 95%CI: 0.745 to 0.963, P=0.011) and OS (HR=0.858, 95%CI: 0.768 to 0.959, P=0.007) were significantly longer with left-sided over opposite-sided pneumonectomy after matching analysis for 2,050 patients
Summary
About 75–80% lung cancer patients belong to nonsmall cell lung cancer (NSCLC) [3]. Pneumonectomy can approximately affect quality of life and long-term survival for several reasons. It has been reported that patients received right or left-sided pneumonectomy may have different prognosis [6, 7], and patients with pneumonectomy in right lung were associated with higher incidence of mortality and morbidity than that in left side[8]. Mainly due to the reason that right lung contributes more to overall lung function than that in the opposite side[9]. Right and left-sided pneumonectomy may have distinctive long-term survival, but this problem has not been fully identified. This study aimed to assess the different survival outcome of stage I-IIIA NSCLC patients who received right-sided and left-sided pneumonectomy, and to further develop the most appropriate treatment strategies
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