Abstract
Abstract not available.
Highlights
Ingenol mebutate (IMB) (0.015% or 0.05%) gel is a topical Actinic keratoses (AKs) treatment used to treat AK on the trunk and extremities, but it can elicit local skin reactions (LSRs) at the application site2-4 – LSRs are associated with erythema, flaking/scaling, crusting, swelling, vesiculation/pustulation, and erosion/ulceration – Managing LSRs during treatment of AK may be important for treatment adherence and setting patient expectations
Patients randomized to receive clobetasol propionate had no benefit over untreated patients in reducing LSRs and their associated pain and pruritus
Dimethicone lotion with IMB had no significant effect on LSR severity over treatment with IMB alone
Summary
Actinic keratoses (AKs) are epidermal lesions on the skin caused by damage from chronic exposure to UV rays from the sun and/or indoor tanning[1]. AKs have a risk of progressing to invasive squamous cell carcinoma (SCC) if untreated; the majority of clinically diagnosed SCCs originate from concomitant AKs1. Ingenol mebutate (IMB) (0.015% or 0.05%) gel is a topical AK treatment used to treat AK on the trunk and extremities, but it can elicit local skin reactions (LSRs) at the application site2-4 – LSRs are associated with erythema, flaking/scaling, crusting, swelling, vesiculation/pustulation, and erosion/ulceration – Managing LSRs during treatment of AK may be important for treatment adherence and setting patient expectations. Previous clinical data have demonstrated that the treatment burden of LSRs associated with IMB gel is minimal, manageable, and short lasting[5]
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