Abstract
Body shape index (ABSI) and triponderal mass index (TMI) have been recently associated with cardiovascular risk in adults. A cross-sectional study was conducted to evaluate the relationship between different anthropometric adiposity indexes and metabolic syndrome (MetS) in Caucasian obese children and adolescents. Consecutive obese children aged ≥7 years have been enrolled. Anthropometric parameters, body composition (by bioelectrical impedance), and systolic and diastolic blood pressure have been measured. Fasting blood samples have been analyzed for lipids, insulin, glucose. A multivariate logistic regression analyses, with body mass index z-score, waist to height ratio, ABSI z-score, TMI, conicity index as predictors for MetS (IDEFICS and IDF criteria according to age) has been performed. Four hundred and three (179 boys and 224 girls) obese children, aged 7–20 years, have been evaluated. When we explored the joint contribution of each anthropometric and adiposity index of interest and BMIz on the risk of MetS, we found that the inclusion of ABSIz improved the prediction of MetS compared to BMIz alone. ABSI-BMI can be a useful index for evaluating the relative contribution of central obesity to cardiometabolic risk in clinical management of obese children and adolescents.
Highlights
Childhood obesity is considered one of the most serious global public health challenges in the21st century [1] in terms of prevalence and economic burden [2,3]
The aim of this study is to evaluate the relationship between different anthropometric adiposity indexes (AAIs) and metabolic syndrome (MetS) and to identify which of the AAIs allows a better assessment of the probability of having MetS in Caucasian obese children and adolescents aged
When we explored the joint contribution of each anthropometric and adiposity index of interest and BMIz on the risk of metabolic syndrome, we found that the inclusion of ABSIz improved the prediction of MetS compared to BMIz alone in children aged ≥ 10 years (Table 4)
Summary
Childhood obesity is considered one of the most serious global public health challenges in the21st century [1] in terms of prevalence and economic burden [2,3]. Initiative (COSI) data collection showed an increase in obesity prevalence in school-aged children (6–9 years) affecting 21% of boys and 19% of girls [5]. Obesity may be associated with adverse health effects during childhood and with an increased risk of metabolic and cardiovascular morbidity and mortality later in life. Obese children can develop dyslipidemia, hypertension, and disorders of glucose metabolism, hallmarks of metabolic syndrome (MetS), more frequently during adolescence [6,7]. These long-term effects, especially if obesity status develops early in life, seem to be related to imbalanced gut microbiome, inflammation, impaired insulin signaling, and metabolic dysregulation [8]. DXA, as well as air displacement plethysmography, is not widely available (partly because of the associated costs) as anthropometry, a simple, noninvasive, and inexpensive technique
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