Abstract
Recent epidemiological evidences have suggested a positive association between the intake of antioxidant nutrients and breast cancer (BC) risk. The purpose of this study was to compare the intake of antioxidant nutrients and oxidative stress and inflammation‐related biomarkers between BC patients (n = 153) and their healthy counterparts (n = 151). The mean caloric and fat intake of BC patients and controls was not significantly different from each other. The intake of folate and antioxidant nutrients including vitamin A, vitamin C and vitamin E were significantly lower in BC patients compared to the control subjects (p<0.001). Plasma concentrations of interleukin (IL)‐1β (p<0.001), IL‐6 (p<0.001) and prostaglandin E2 (p<0.05) were significantly higher in the BC patients. A significantly higher level of plasma concentrations of 8‐OHdG (8‐hydroxy‐2′‐deoxyguanosine, p<0.001) was observed in BC patients. Positive correlations were observed between inflammatory biomarkers, while antioxidant nutrient intakes were not related to the level of inflammatory markers. IL‐6 level was positively associated with the intake of total calorie, fat, or carbohydrate. Our results suggest that oxidative stress and inflammatory response may be related to the BC progress and dietary factors may play a role. This work was supported by the SRC/ERC program of MOST/KOSEF (RESEARCH CENTER FOR WOMEN's DISEASES)
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