Abstract
Objective To quantify the diastolic average energy loss (EL) of left ventricle in patients with pregnancy-induced hypertension (PIH) by vector flow mapping (VFM) technique and explore the clinical significance of EL in evaluating left ventricular diastolic function in patients with PIH. Methods Fifty-seven cases of singletonic PIH in late pregnancy (PIH group) and 38 cases of the third trimester normal singleton pregnancy (control group) were enrolled in this study. VFM were used to analyze the total average energy loss (ELt) and average energy loss at the basal level (ELb), the papillary muscle level (ELp), and the apical level (ELa) in isovolumic relaxation, rapid filling, mid-diastol and atrial systole phases, and the differences between the two groups were compared. The correlation between ELt and E/e in both groups were analyzed. Results In PIH group, ELt, ELb, ELp and ELa in the mid-diastolic and atrial systolic phases were significantly higher than those in control group (all P<0.01); ELt, ELp, ELa in isovolumic diastolic phase and ELt, ELb and ELa in fast filling phase were higher than those in control group (all P<0.05). There was a positive correlation between ELt and E/e in isovolumic diastolic phase, rapid filling phase and atrial systolic phase in PIH group (r=0.326, 0.386, 0.403; all P<0.05). There was a positive correlation between the ELt of fast filling and atrial systolic phases and E/e in control group (r=0.498, 0.371; all P<0.05). Conclusions Increased left ventricular diastolic flow EL in PIH patients reflects the abnormal intraventricular hemodynamic changes, and it is related to left ventricular diastolic function parameters for the quantitatively evaluation of PIH patients, and might be feasible to reveal the extent and mechanism of left ventricular diastolic dysfunction. Key words: Vector flow mapping; Pregnancy-induced hypertension; Ventricular function, left; Energy loss
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