Abstract
Evaluation of Diaphragmatic electromyography of cervical spinal cord hemi section in Rat model
Highlights
Spinal cord injury (SCI) usually leads to loss of motor and sensory function below the site of injury [1] leading to degenerative processes affecting ascending and descending pathways that carry information between the brain and the spinal cord[2].Unilateral hemi section of high cervical spinal cord results in the immediate cessation of ipsilateral phrenic activity and paralysis of the hemi diaphragm due to phrenic motor neuron (PhMN) loss and consequent denervation at the diaphragm neuromuscular consequent silencing of spared PhMNs[3].A broad spectrum strategies has been potentially examined to enhance recovery in animal models with spinal cord injury.Estimation of the cervical spine traumatic damage and evaluation of the induced recovery is needed
The neutrophil adjacent to the necrotic neurons lost its homogeneous appearance and appeared vacuolated or edematous with significant decrease in the number of viable motor neurons compared to the control group
Glial fibrillary acidic protein (GFAP) immune expression for hemi-sectioned group was significantly increased than control group (P < 0.05)
Summary
Unilateral hemi section of high cervical spinal cord results in the immediate cessation of ipsilateral phrenic activity and paralysis of the hemi diaphragm due to phrenic motor neuron (PhMN) loss and consequent denervation at the diaphragm neuromuscular consequent silencing of spared PhMNs[3].A broad spectrum strategies has been potentially examined to enhance recovery in animal models with spinal cord injury. Estimation of the cervical spine traumatic damage and evaluation of the induced recovery is needed. EMG recording after spinal cord hemi section translate the degree of damage of traumatic injury of cervical segments [4]. The aim of current study is to evaluate the functional state of diaphragmatic muscles through EMG after spinal cord hemi section and correlate it to the histological structure and the immunohistochemistry for GFAP immune peroxidase of cervical cord
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