Evaluation of Deformable Image Registration Between High Dose Rate Brachytherapy and Intensity Modulated Radiation Therapy for Prostate Cancer

Abstract

High risk prostate cancer is treated with a combination of intensity-modulated radiation therapy (IMRT) and high dose rate brachytherapy (HDR-BT). Deformable image registration (DIR) techniques used for dose accumulation sums dose distributions. The accuracy of DIR would get worse when density of an organ in a pair of registering two images differs greatly each other. Needles and contrast medium are used in HDR-BT. In this study, the effect of needles and contrast medium for DIR accuracy was evaluated. Six patients with prostate cancer were enrolled, who were treated with the combination of HDR-BT and IMRT. In the HDR-BT plan, needleless image (NI) and needleless and no-contrast medium image (NCI) were created from the original HDR-BT plan image (OI) to investigate the influence of needles and contrast medium. Both DIR and rigid registration (RR) were performed on the OI, NIs and NCIs by using MIM Maestro ver. 6.7.6 (MIM software Inc, Cleveland, USA) and after that the dose distribution of HDR-BT (used as the reference image) and IMRT were accumulated. The Dice Similarity coefficient (DSC) between DIR and RR were analyzed and compared each other. The mean DSC values of the prostate with DIR on OI, NI and NCI were 0.51, 0.57 and 0.73, respectively. The DSC with DIR on NCI was higher than DSC with DIR on OI and NI. The DSC values improved by removing the contrast medium.