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Abstract
Danzhi Xiaoyao powder (DXP) is an herbal formula with eight different herbs. This herbal medicine can play multiple roles in various disease treatments through its several components. In this study, the effect of DXP was evaluated on the treatment of hypertensive patients with and without amlodipine. For this purpose, 252 patients were studied with high blood pressure. The 126 patients received DXP, and the others received DXP + amlodipine for four weeks. Besides demographic and biochemical assessments (gender, BMI, age, SBP, DBP, etc.), the expression of the interleukin-6 gene was evaluated in these two groups. The results showed that the blood pressure decreased by DPX, and there was no significant difference in control of blood pressure by DPX and DXP + amlodipine. But it did not affect interleukin-6 gene expression. Therefore, it can be concluded that this drug probably uses a different mechanism than amlodipine to control blood pressure.
Highlights
Arterial blood pressure is an important indicator in assessing the cardiovascular status of individuals (1, 2)
The results showed that the blood pressure decreased by DPX, and there was no significant difference in control of blood pressure by DPX and Danzhi Xiaoyao powder (DXP) + amlodipine
The second point is about the effect of DXP on controlling blood pressure in hypertensive patients, which shows that this drug has been able to control blood pressure
Summary
Arterial blood pressure is an important indicator in assessing the cardiovascular status of individuals (1, 2). Blood pressure is affected by two factors: cardiac output and peripheral vascular resistance. Cardiac output is largely controlled by factors such as heart rate and inotropic status that are affected by calcium concentration (1). Important reasons have been suggested that the cause of increased environmental resistance is vascular stenosis due to increased intracellular calcium concentrations. This may be due to an inherited defect in the cell membrane or a genetic change in the structure of the sodium-potassium pump, hormonal and neurological factors may play a role in increasing intracellular calcium concentrations and increasing peripheral vascular resistance (4)
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Schedule a callMore From: Cellular and molecular biology (Noisy-le-Grand, France)
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