Abstract
Background: Accurate diagnosis of deep vein thrombosis minimizes the risk of thrombo embolic complications and averts the exposure of patients without thrombosis to the risks of anticoagulant therapy. Recent studies have shown the safety of using D-dimer assay in ruling out suspected DVT. Objective: Evaluate the usefulness of using D-dimer (VIDAS) assay compared to duplex ultrasonography in the early diagnosis of suspected DVT in Egyptian sample size. Patients and methods: One hundred patients with suspected deep vein thrombosis have got assessment with (i) Wells' clinical probability guide for DVT diagnosis, (ii) VIDAS D-dimer essay & (iii) duplex scanning. The results of D-dimer testing & duplex scanning were evaluated & compared on the basis of patients' clinical features. Results: The validity of D-dimer testing in diagnosing likely patients in relation to duplex ultrasound showed that D-dimer test has reached 100% sensitivity, 91% specificity & 99% accuracy in comparison to duplex study. Alternatively for unlikely patiens; D-dimer test showed 100% sensitivity, 89% specificity & 92% accuracy in comparison to duplex study. Conclusion: The incorporation of information gathered from Wells' clinical score, duplex scanning & D-dimer assay should be helpful in the diagnosis of suspected DVT
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